Defender Winston Reid made his return from suspension against Arsenal in midweek, and is once again available for selection on Saturday. He may have trouble dislodging the duo of James Collins and Angelo Ogbonna, though.
Jose Fonte and Sam Byram are definitely out.
Arthur Masuaku has impressed during The Hammers' unbeaten run in the league. He looks set to start once more in the left wing-back role, with Pablo Zabaleta operating on the opposite flank.
Captain Mark Noble is doubtful for the game, but Cheikhou Kouyate looks set to be passed fit, so he could slot straight back into the midfield, alongside Pedro Obiang.
West Ham will be without playmaker Manuel Lanzini after his two-game suspension for diving was upheld by the FA. David Moyes may opt to bring Javier Hernandez back into the team in his absence.
Marko Arnautovic was an early doubt for the game, but looks set to be fit at the London Stadium. The Austrian has been in sensational form recently.
Rob Elliot looks set to keep his place in between the sticks for the Magpies, but both he and Karl Darlow will know that they could be sold in January, with Benitez searching for a new goalkeeper.
Paul Dummett could be ready to play for the first time since the opening day of the season after recovering from his hamstring injury. If the Welshman is not deemed fit enough, Javier Manquillo will continue at left-back.
Jamaal Lascelles has helped to shore up the Newcastle defence in his return from injury. He will partner with Florian Lejeune, who looked much improved at the Emirates last weekend. Ciaran Clark will have to wait for his chance.
Jonjo Shelvey will not be able to play, as he serves his second suspension of the season after his red card against Everton. Mikel Merino and Isaac Hayden look set to play in the midfield once more.
Matt Ritchie was dropped to the bench last weekend, but looked lively when he was introduced. Christian Atsu struggled against The Gunners, so may have to sit this one out.
Joselu worked hard in the 1-0 defeat, but with Newcastle expected to create more chances at West Ham, Dwight Gayle would probably be the better option to play as the lone striker.
Aleksandar Mitrovic has been ruled out with a back problem. Make of that what you will.
Likely line ups:
West Ham: Adrian, Zabaleta, Reid, Ogbonna, Cresswell, Masuaku, Obiang, Kouyate, Ayew, Arnautovic, Hernandez
Newcastle: Elliot, Yedlin, Lascelles, Lejeune, Dummett, Hayden, Merino, Ritchie, Perez, Murphy, Gayle
Score prediction: West Ham United 0-0 Newcastle United
The game has not been selected for TV coverage. You can also follow the match by tuning into BBC Radio Newcastle's live commentary, courtesy of the official NUFC website.