Paul Dummett made the bench last time out, and will likely do so again. Javier Manquillo will probably be the one to start at left-back though, with Jesus Gamez definitely out.
Florian Lejeune's injury is said to be enough for him to be considered a doubt for the City clash. If the Frenchman does not pass a fitness test, Ciaran Clark will continue alongside Jamaal Lascelles.
Newcastle will be able to welcome back Jonjo Shelvey after his latest suspension, but he will likely have to settle for a place on the bench.
Mikel Merino and Isaac Hayden were both forced to sit out the win over West Ham at the weekend, but could both come straight back into the side. Henri Saivet could well have played himself back into his manager's thinking though, after an excellent goal against The Hammers.
Matt Ritchie and Christian Atsu were both brilliant at the London Stadium and will undoubtedly start against Pep Guardiola's side. Jacob Murphy will have to force his way back into the XI.
Dwight Gayle played up front with Joselu on Saturday, and the pair have struck up a good partnership in recent weeks. It would not be a surprise to see them both on the team-sheet once again. Aleksandar Mitrovic remains out with a back problem.
John Stones is back in training after a nasty hamstring injury, but the Newcastle game will come too quickly for the defender. Vincent Kompany may not be able to play two games in a week, so Eliaquim Mangala would then slot in beside Nicolas Otamendi.
Benjamin Mendy is a long-term absentee, and Fabian Delph has really improved in his place. The former Villa man will likely start in the left-back role, with Danilo also being an option for Guardiola.
Youngster Phil Foden has suffered an injury that will see him miss a significant amount of time, so he will not feature.
A midfield trio of Fernandinho, Kevin De Bruyne and David Silva would terrify any team right now, so Newcastle's midfielders will know just how big of a job they will have containing them. Yaya Toure is also available to bring off of the bench.
Leroy Sane and Raheem Sterling will offer pace and trickery on the flanks, supporting either the magnificent Sergio Aguero or the superb Gabriel Jesus.
Likely line ups
Newcastle: Elliot, Yedlin, Lascelles, Clark, Manquillo, Hayden, Merino, Ritchie, Joselu, Atsu, Gayle
Man City: Ederson, Walker, Kompany, Otamendi, Delph, Fernandinho, De Bruyne, Silva, Sterling, Sane, Aguero
Score prediction: Newcastle United 0-3 Man City
The game has been selected for Sky Sports TV coverage. You can also follow the match by tuning into BBC Radio Newcastle's live commentary, courtesy of the official NUFC website.