Rafa Benitez will likely revert to a full strength XI for the midweek game. Daryl Murphy will return in place of Aleksandar Mitrovic and the Lascelles/Clark partnership will be reinstated.
Matt Ritchie and Yoan Gouffran come off the bench against Oxford, but will both play from the start at St James' Park.
Jonjo Shelvey will also return after he was an unused substitute at the Kassam Stadium.
Dwight Gayle, Rolando Aarons and Vurnon Anita remain sidelined and Cheick Tiote is en route to China to complete a move to Shandong Luneng.
As for the visitors, there could well be two new faces in their starting line-up.
Midfielders Sean Goss and Luke Freeman, signed from Manchester United and Bristol City respectively, are available for the game.
Other new signing, Matt Smith, will have to wait to make his Rangers bow however. Northern Irishman Conor Washington will therefore be pushing for a start.
Steven Caulker will not play either, after making a loan move to Lokomotiv Moscow in Russia.
Holloway has concerns over the fitness of Idrissa Sylla, Grant Hall and Jack Robinson. They are all unlikely to feature.
The back four will probably remain unchanged from their 2-1 defeat against Burton Albion, with Nedum Onuoha captaining the side.
Jamie Mackie could be recalled, with Kazenga LuaLua likely to play against his former club.
Likely line ups
Newcastle: Darlow, Yedlin, Lascelles, Clark, Dummett, Shelvey, Hayden, Ritchie, Perez, Gouffran, Murphy
QPR: Smithies, Furlong, Onuoha, Lynch, Bidwell, Luongo, Freeman, Wszolek, Mackie, LuaLua, Washington
Score prediction: Newcastle 2-0 QPR
The match has been selected for TV. It will be shown on Sky Sports 1 in the UK. You can also follow BBC Radio Newcastle's live commentary, courtesy of the official NUFC website.