Both teams looked fairly dangerous in the opening moments. Newcastle's Matt Ritchie fired a shot at goal, but Ayoze Perez got in the way. Eric Maxim Choupo-Moting then forced a corner at the other end of the field.
DeAndre Yedlin looked very sharp down the right-hand side, the American's pace was proving a very useful attacking tool for United.
Just after a quarter of an hour, the home side did break the deadlock, when the superb Ritchie delivered a cross to the back post, and there was Christian Atsu to slot in and score his first ever Premier League goal.
Seconds later, Jamaal Lascelles rose highest to meet Ritchie's corner, but his header crept inches wide of the post. That would have really dealt a blow to Stoke's confidence.
The Potters did begin to grab a foothold in the game after that. Xherdan Shaqiri was their brightest player, and he come close to equalising, only for Rob Elliot to save his left-footed strike.
The end to end nature of the game continued, as former Stoke striker Joselu prodded wide, just before being denied by Jack Butland's legs. The Spaniard will feel he should have scored at least one of his chances today.
Newcastle were well worth their lead at half-time.
The second half began much like the first-half ended. Joselu again with a chance, but this time he blazed a shot over the bar.
Just before the hour mark, Newcastle were eventually made to pay for their missed chances. That man Shaqiri found space on the edge of the 18-yard box and placed a shot into the bottom corner to level it up. 1-1.
Both sides chased a winner, and Rafa Benitez was adamant his team should have had a penalty awarded after Christian Atsu appeared to be felled in the box, but nothing was given.
In years gone by, Newcastle supporters would have grown frustrated and anxious. Not today. The fans rallied behind their team, and they answered.
For the second consecutive week, captain Jamaal Lascelles got himself on the score sheet, courtesy of a Ritchie corner. Newcastle were back in the lead.
Jonjo Shelvey was introduced immediately after the goal, to partner Mikel Merino in the middle of the park. He was tasked with keeping the ball and helping his side see the game out.
Mark Hughes threw on Peter Crouch to try and grab an equaliser late on, but the big man was provided with insufficient quality from crosses.
The man between the sticks come to Newcastle's rescue again, when Choupo-Moting was played through, but Elliot rushed out well to clear the danger.
The aforementioned Choupo-Moting then had a wonderful chance from 10 yards after a route one ball from Butland was won in the air by Crouch, but the Cameroonian skied his shot.
Newcastle survived the aerial barrage from Stoke to clinch their third straight victory. After a less than ideal start to the season, the Magpies are well and truly up and running now.