Brighton manager Chris Hughton has confirmed that forward Izzy Brown is back in the frame and could make his return at the Amex on Sunday. The Chelsea loanee has not featured since the opening weekend of the season.
If he does play from the start, then he would be most likely to take the place of Solly March on the left-wing.
Gaetan Bong did play in that game, and managed to come through it unscathed. He could make his first Premier League appearance. Albion captain Bruno is also available after back issues.
Anthony Knockaert will provide creativity from the right. The Frenchman is undoubtedly a danger man, as is Pascal Groß, who has two goals and two assists for his new club already.
Glenn Murray is also in line to return, after missing the midweek defeat at Bournemouth due to an ankle problem. Tomer Hemed is the more likely option to play in the lone striker role.
Long-term absentees include Steve Sidwell, Beram Kayal and Sam Baldock.
Rafa Benitez's side will travel to Brighton with an almost full squad to choose from.
Goalkeeper Karl Darlow is back after a leg injury, but is unlikely to shift Rob Elliot from the XI.
Florian Lejeune and DeAndre Yedlin have both returned to the first-team fold in recent weeks, whilst Chancel Mbemba also made an early return against Stoke City last weekend. The American will probably start the game, but Lejeune could miss this game as he is still not 100% fit after the Harry Kane tackle on the opening day.
Paul Dummett and Massadio Haidara are the only defenders missing for Newcastle.
Jonjo Shelvey is pushing for his first start since returning from suspension, with Isaac Hayden the more likely, if anybody, that he would replace.
Matt Ritchie has already bagged himself four assists this season. He will continue on the right flank, with Christian Atsu operating on the opposite side of the pitch.
Aleksandar Mitrovic is set to complete his ban this week, but will be in line to return against Liverpool at St James' Park next weekend. Joselu did miss some big chances in the win over Stoke, but is likely to keep his place up front.
Likely line ups
Brighton: Ryan, Bruno, Dunk, Duffy, Suttner, Knockaert, Stephens, Propper, March, Groß, Hemed
Newcastle: Elliot, Yedlin, Lascelles, Clark, Mbemba, Hayden, Merino, Ritchie, Ayoze, Atsu, Joselu
Score prediction: Brighton and Hove Albion 1-1 Newcastle United
The game has been selected for Sky Sports TV coverage. You can also follow the match by tuning into BBC Radio Newcastle's live commentary, courtesy of the official NUFC website.