DeAndre Yedlin has recovered from a knee injury sustained on the opening weekend and will return at right-back.
Federico Fernandez and Fabian Schär are both still waiting to make their Magpies debut. Given the limited options available to Rafa Benitez at right back, it is likely that both will make the matchday squad.
Mo Diame is yet to really get going this season, and will again be fearful of losing his place to Ki Seung-Yeung. The South Korean is also still waiting to make his bow.
On-loan Newcastle winger Kenedy, who will still be recovering mentally from his bad performance against Cardiff, is ineligible against his parent club. Christian Atsu and Jacob Murphy are both options to deputise.
Salomon Rondon could be in line to make his first start for his new club.
For the visitors, David Luiz has been brought back in from the cold after a year of exile under Antonio Conte. He will continue his partnership with Antonio Rudiger in the centre of defence.
Cesar Azpilicueta and Marcos Alonso have been extremely consistent for Chelsea over the past few seasons and will both play from the beginning again.
Cesc Fabregas remains out, with Jorginho, N’Golo Kante and Matteo Kovacic set to form a very impressive midfield trio.
Ross Barkley will therefore have to drop out of the XI.
Chelsea boss Maurizio Sarri is expected to give Eden Hazard his first start of the season after two substitute cameos. He will likely start in place of Willian.
Likely line ups
Newcastle: Dubravka, Yedlin, Lascelles, Fernandez, Dummett, Shelvey, Diame , Ritchie, Perez, Atsu, Rondon
Chelsea: Kepa, Azpilicueta, Rudiger, Luiz, Alonso, Jorginho, Kovacic, Kante, Willian, Morata, Hazard
Score prediction: Newcastle United 0-2 Chelsea
How to watch:
The match will be broadcasted live on Sky Sports, as well as NBC sports for our American readers and you can also follow along by tuning into BBC Radio Newcastle’s live commentary, courtesy of the official NUFC website.